1-(2-Hydroxy-4,6-dimethoxyphenyl)-2-(4-methoxyphenyl)ethanone

CAS NO.：39604-68-7
Empirical Formula: C17H18O5
Molecular Weight: 302.32
MDL number: MFCD03934798
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-08 17:06:37

What is 1-(2-Hydroxy-4,6-dimethoxyphenyl)-2-(4-methoxyphenyl)ethanone?

Preparation

Preparation by partial methylation of 2,4,6-tri-hydroxyphenyl 4-methoxybenzyl ketone,
? with dimethyl sulfate in the presence of potassium carbonate in refluxing acetone, for 3 h (64%);
? with diazomethane in ethyl ether at 0° (80%) or in methanol;
? with methyl iodide in the presence of potassium carbonate in refluxing acetone for 3 h (42%).

Properties of 1-(2-Hydroxy-4,6-dimethoxyphenyl)-2-(4-methoxyphenyl)ethanone

Melting point:	85.0 to 89.0 °C
Boiling point:	494.8±40.0 °C(Predicted)
Density	1.199±0.06 g/cm3(Predicted)
solubility	soluble in Toluene
form	powder to crystal
pka	7.07±0.40(Predicted)
color	White to Almost white
λmax	286nm(MeOH)(lit.)
CAS DataBase Reference	39604-68-7

Safety information for 1-(2-Hydroxy-4,6-dimethoxyphenyl)-2-(4-methoxyphenyl)ethanone

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.