1-(2-Furoyl)piperazine

Synonym(s):1-(2-Furoyl)piperazine;2-Furoic piperazide

CAS NO.：40172-95-0
Empirical Formula: C9H12N2O2
Molecular Weight: 180.2
MDL number: MFCD00038831
EINECS: 254-823-7
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is 1-(2-Furoyl)piperazine?

Chemical properties

white to light yellow solid

The Uses of 1-(2-Furoyl)piperazine

1-(2-Furoyl)piperazine may be used to synthesize:

2-[4-(2-furoyl) piperazin-1-yl]-4-amino-6-benzyloxy-7-methoxyquinazoline hydrochloride monohydrate
2-[4-(2-furoyl)piperazin-1-yl]-4-amino-7-benzyloxy-6-methoxyquinazoline hydrochloride monohydrate
4-amino-2-[4-(2-furoyl)piperazin-1-yl]-quinazoline hydrochloride
6,7-dimethoxy-2-[4-(2-furoyl)-piperazin-1-yl]quinazoline-4-one hydrate
1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(2-furoyl)-piperazine hydrogen oxalate
1-(3,4-dichlorobenzyl)-4-(2-furoyl)-piperazine hydrogen oxalate
4-(9-fluorenyl)-1-(2-furoyl)piperazine
2-[4-(2-furoyl)piperazin-1-yl]-benzimidazole hydrochloride hydrate

The Uses of 1-(2-Furoyl)piperazine

2-Furanyl-1-piperazinylmethanone was utilized in the fragment-based design of symmetrical bis-benzimidazole as inhibitors of R67 dihydrofolate reductase.

The Uses of 1-(2-Furoyl)piperazine

2-Furanyl-1-piperazinylmethanone (Terazosin EP Impurity L) was utilized in the fragment-based design of symmetrical bis-benzimidazole as inhibitors of R67 dihydrofolate reductase.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 20, p. 146, 1977 DOI: 10.1021/jm00211a031

Properties of 1-(2-Furoyl)piperazine

Melting point:	67-70 °C(lit.)
Boiling point:	137-140°C 0,1mm
Density	1.1819 (rough estimate)
refractive index	1.5373 (estimate)
Flash point:	>230 °F
storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility	Chloroform, Methanol (Slightly)
form	neat
pka	8.37±0.10(Predicted)
color	White to Pale Yellow
Sensitive	Hygroscopic
BRN	880196
Stability:	Very Hygroscopic
CAS DataBase Reference	40172-95-0(CAS DataBase Reference)

Safety information for 1-(2-Furoyl)piperazine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.