1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE
- CAS NO.:105628-72-6
- Empirical Formula: C14H17N3O3S
- Molecular Weight: 307.37
- MDL number: MFCD01752417
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:17
What is 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE?
Biological Activity
Cell-permeable active metabolite of Fasudil (HA 1077; Fasudil hydrochloride). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo .
Properties of 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | Soluble in DMSO |
form | Solid |
color | White to off-white |
Safety information for 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE
New Products
(R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Tubulysin B Tubulysin D Tubulysin I Diethyl Aluminium Cyanide (1.0 M in Toluene) 2,2-Difluoropropanol 4,4-DIFLUOROPIPERIDINE 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE 2,2-Difluoropropylamine hydrochloride 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 4-(Benzyloxy)-3-bromophenylacetic Acid 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Fuel shell Magnesium Trisilicate Latanoprostene Bunod Lubiprostone Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
5-Quinolinesulfonic acid, 2-methyl-
Fasudil N-hydroxy iMpurity
Fasudil diMer
1,4-ditosyl-1,4-diazepane
Fasudil Pyridine N-Oxide TFA Salt
Fasudil Impurity 13
Fasudil Impurity 6
Fasudil Impurity 6
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