1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE

CAS NO.：105628-72-6
Empirical Formula: C14H17N3O3S
Molecular Weight: 307.37
MDL number: MFCD01752417
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-02 08:55:17

What is 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE?

Biological Activity

Cell-permeable active metabolite of Fasudil (HA 1077; Fasudil hydrochloride). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo .

Properties of 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE

storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Soluble in DMSO
form	Solid
color	White to off-white

Safety information for 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE

New Products

S-BENZYL THIURONIUM CHLORIDE SODIUM CACODYLATE TOPFERS REAGENT PHENOLPHTHALEIN PH INDICATOR ALUMINIUM OXIDE ACTIVE ACIDIC PHENYLHYDRAZINE HYDROCHLORIDE

Related products of tetrahydrofuran

5-Quinolinesulfonic acid, 2-methyl-

Fasudil N-hydroxy iMpurity

Fasudil diMer

1,4-ditosyl-1,4-diazepane

Fasudil Pyridine N-Oxide TFA Salt

Fasudil Impurity 13

Fasudil Impurity 6