1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazoletrihydrochloride

Synonym(s):1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole trihydrochloride hydrate

CAS NO.：1028969-49-4
Empirical Formula: C26H40N4
Molecular Weight: 408.62
MDL number: MFCD11840549
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 23:16:16

1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazoletrihydrochloride Structural

What is 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazoletrihydrochloride?

The Uses of 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazoletrihydrochloride

A potent non-peptide nociceptin/orphanin FQ peptide (NOP)-receptor full agonist [or opioid-receptor-like-1 (ORL1) receptor agonist]. It is the most potent, non-peptide NOP full agonists in vitro and a potent anxiolytic in the mice. It inhibited signaling through the NOP receptor in the mouse brain, suggesting that it penetrated into the brain after it was orally administered. It did not affect locomotor activity or memory, nor did it contribute to ethanol-induced hypnosis.

Properties of 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazoletrihydrochloride

Melting point:	>249°C (dec.)
Boiling point:	576.5±50.0 °C(Predicted)
Density	1.18
storage temp.	Store at -20°C
solubility	H2O: ≥13mg/mL
form	powder
pka	9.67±0.10(Predicted)
color	white to tan

Safety information for 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazoletrihydrochloride

Computed Descriptors for 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazoletrihydrochloride

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4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION Methylcobalamin (vitamin B12) SODIUM METHYL PARABEN SODIUM VALPROATE AMOXICILLIN (AMOXYCILLIN) TRIHYDRATE ACICLOVIR