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HomeProduct name listΑ-ENDORPHIN

Α-ENDORPHIN

  • Molecular Weight: 0

What is Α-ENDORPHIN?

Description

Endorphin is an endogenous morphine secreted from the pituitary. Sources are corticotropes in the pars distalis and melanotropes in the pars intermedia. The fact that END is derived from a precursor protein called proopiomelanocortin (POMC) was demonstrated in 1979 using the pars intermedia in the bovine pituitary.

Clinical Use

There is a correlation between endogenous opioid peptides, especially β-END, and alcohol abuse. The consumption of alcohol activates the endogenous opioid system. The consumption of alcohol results in an increase in β-END levels in the brain regions that are associated with reward. However, it has also been observed that habitual alcohol consumption leads to β-END deficiency. People with a genetic deficit in β-END are particularly susceptible to alcoholism. The plasma levels of β-END in subjects genetically at high risk of excessive alcohol consumption show lower basal activity of β-END. Recently, β-END has been shown to play a role in the pathophysiology of major depressive disorder in addition to a variety of physiological functions such as cardiovascular regulation and several kinds of behavior and stress responses.

Safety information for Α-ENDORPHIN

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