Α-ENDORPHIN
- Molecular Weight: 0
What is Α-ENDORPHIN?
Description
Endorphin is an endogenous morphine secreted from the pituitary. Sources are corticotropes in the pars distalis and melanotropes in the pars intermedia. The fact that END is derived from a precursor protein called proopiomelanocortin (POMC) was demonstrated in 1979 using the pars intermedia in the bovine pituitary.
Clinical Use
There is a correlation between endogenous opioid peptides, especially β-END, and alcohol abuse. The consumption of alcohol activates the endogenous opioid system. The consumption of alcohol results in an increase in β-END levels in the brain regions that are associated with reward. However, it has also been observed that habitual alcohol consumption leads to β-END deficiency. People with a genetic deficit in β-END are particularly susceptible to alcoholism. The plasma levels of β-END in subjects genetically at high risk of excessive alcohol consumption show lower basal activity of β-END. Recently, β-END has been shown to play a role in the pathophysiology of major depressive disorder in addition to a variety of physiological functions such as cardiovascular regulation and several kinds of behavior and stress responses.
Safety information for Α-ENDORPHIN
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound AYou may like
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