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HomeProduct name list(-)-Bicucullinemethiodide

(-)-Bicucullinemethiodide

(-)-Bicucullinemethiodide Structural

What is (-)-Bicucullinemethiodide?

The Uses of (-)-Bicucullinemethiodide

1(S),9(R)-(-)-Bicuculline methiodide has been used as a gamma-aminobutyric acid (GABA) antagonist to block inhibition in the semicoronal slices. It has also been used for the preparation of organotypic hippocampal slice cultures (OHSCs).

What are the applications of Application

(?)-Bicuculline methiodide is a N-methylated derivative of the GABAA antagonist (+)-bicuculline

General Description

Bicuculline is a phthalide isoquinoline alkaloid, which is extracted from Dicentra cucullaria. It acts as an acetylcholinesterase?inhibitor. Bicuculline inhibits slow afterhyperpolarization (AHP).

Biological Activity

Methiodide form of classical GABA A receptor antagonist (+)-bicuculline ([R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one ). More water-soluble and stable. Non-GABA receptor-mediated actions reported, including actions on calcium-dependent potassium channels.

Biochem/physiol Actions

(-)-Bicuculline methiodide is a GABAA receptor antagonist, which acts as a competitive inhibitor of GABA ligand binding to the receptor.

storage

Room temperature

Properties of (-)-Bicucullinemethiodide

RTECS  JI4904100
storage temp.  Store at RT
solubility  H2O: soluble10mg/mL, almost clear, greenish-yellow
form  Pale yellow solid.
color  Yellow
optical activity [α]/D -117±7°, c = 1 in chloroform
BRN  5419649

Safety information for (-)-Bicucullinemethiodide

Signal word Warning
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Environment
GHS09
GHS Hazard Statements H301:Acute toxicity,oral
H311:Acute toxicity,dermal
H330:Acute toxicity,inhalation
H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes P320:Specific treatment is urgent (see … on this label).
P330:Rinse mouth.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P405:Store locked up.

Computed Descriptors for (-)-Bicucullinemethiodide

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