(-)-Bicucullinemethiodide
- CAS NO.:40709-69-1
- Empirical Formula: C21H20INO6
- Molecular Weight: 0
- MDL number: MFCD00078966
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 16:48:35
What is (-)-Bicucullinemethiodide?
The Uses of (-)-Bicucullinemethiodide
1(S),9(R)-(-)-Bicuculline methiodide has been used as a gamma-aminobutyric acid (GABA) antagonist to block inhibition in the semicoronal slices. It has also been used for the preparation of organotypic hippocampal slice cultures (OHSCs).
What are the applications of Application
(?)-Bicuculline methiodide is a N-methylated derivative of the GABAA antagonist (+)-bicuculline
General Description
Bicuculline is a phthalide isoquinoline alkaloid, which is extracted from Dicentra cucullaria. It acts as an acetylcholinesterase?inhibitor. Bicuculline inhibits slow afterhyperpolarization (AHP).
Biological Activity
Methiodide form of classical GABA A receptor antagonist (+)-bicuculline ([R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one ). More water-soluble and stable. Non-GABA receptor-mediated actions reported, including actions on calcium-dependent potassium channels.
Biochem/physiol Actions
(-)-Bicuculline methiodide is a GABAA receptor antagonist, which acts as a competitive inhibitor of GABA ligand binding to the receptor.
storage
Room temperature
Properties of (-)-Bicucullinemethiodide
RTECS | JI4904100 |
storage temp. | Store at RT |
solubility | H2O: soluble10mg/mL, almost clear, greenish-yellow |
form | Pale yellow solid. |
color | Yellow |
optical activity | [α]/D -117±7°, c = 1 in chloroform |
BRN | 5419649 |
Safety information for (-)-Bicucullinemethiodide
Signal word | Warning |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 Environment GHS09 |
GHS Hazard Statements |
H301:Acute toxicity,oral H311:Acute toxicity,dermal H330:Acute toxicity,inhalation H400:Hazardous to the aquatic environment, acute hazard |
Precautionary Statement Codes |
P320:Specific treatment is urgent (see … on this label). P330:Rinse mouth. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P405:Store locked up. |
Computed Descriptors for (-)-Bicucullinemethiodide
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