(-)-4-BROMOTETRAMISOLE OXALATE
Synonym(s):(−)-4-Bromotetramisole oxalate;(-)-4-Bromotetramisole oxalate;S(−)-6-(4-Bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole oxalate;6-Bromolevamisole oxalate;S(-)-6-(4-Bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole oxalate
- CAS NO.:62284-79-1
- Empirical Formula: C13H13BrN2O4S
- Molecular Weight: 373.22
- MDL number: MFCD00070406
- EINECS: 263-487-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-04 20:04:50
What is (-)-4-BROMOTETRAMISOLE OXALATE?
Description
Four distinct human isoenzymes of alkaline phosphatase (AP) are known: intestinal (IAP), placental (PLAP), tissue non-specific (NSAP, also known as liver/bone/kidney AP), and germ cell AP (also known as placental-like AP, PLAP-like). L-p-Bromotetramisole is a cell-permeable inhibitor of all four human AP isoenzymes (Kis =18 and 56 μM for PLAP and NSAP, respectively). While PLAP is strongly inhibited by L-p-bromotetramisole, a second AP, possibly PLAP-like, shows only partial inhibition. L-p-Bromotetramisole has been shown to inhibit a tyrosine phosphatase from Drosophila and, as a result, is also used as a tyrosine phosphatase inhibitor.
Chemical properties
white to light yellow crystal powde
The Uses of (-)-4-BROMOTETRAMISOLE OXALATE
L-p-Bromotetramisole Oxalate or (-)-p-Bromotetramisole Oxalate is a potent inhibitor of alkaline phosphatase.
What are the applications of Application
L-p-Bromotetramisole oxalate is a potent and non-specific alkaline phosphatase inhibitor that strongly activates CFTR chloride channels.
Biochem/physiol Actions
(-)-p-Bromolevamisole oxalate inhibits L-isoforms of alkaline phosphatases.
References
1) Kovach?et al. (1992),?Levamisole potentiation of fluorouracil antiproliferative activity mimicked by orthovanadate, an inhibitor of tyrosine phosphatase; J. Natl. Cancer Inst.,?84?515 2) Luo et al. (2000),?Role of protein phosphatases in the activation of CTFR (ABCC7) by genistein and bromotetramisole;?Am. J. Physiol. Cell Physiol.,?279?C108 3) Scher?et al.?(1998),?The phosphatase inhibitors, orthovanadate and levamisole, inhibit induction of erythroid differentiation and abrogate the associated inhibition of glycolysis; Int. J. Oncol.,?12?987
Properties of (-)-4-BROMOTETRAMISOLE OXALATE
Melting point: | 192 °C (dec.) (lit.) |
Flash point: | 87℃ |
storage temp. | 2-8°C |
solubility | Soluble in Water (up to 10 mg/ml) |
form | liquid |
color | White |
optical activity | [α]25/D 104°, c = 0.5 in H2O |
BRN | 4944883 |
Stability: | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months. |
Safety information for (-)-4-BROMOTETRAMISOLE OXALATE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
Computed Descriptors for (-)-4-BROMOTETRAMISOLE OXALATE
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