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HomeProduct name list(-)-4-BROMOTETRAMISOLE OXALATE

(-)-4-BROMOTETRAMISOLE OXALATE

Synonym(s):(−)-4-Bromotetramisole oxalate;(-)-4-Bromotetramisole oxalate;S(−)-6-(4-Bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole oxalate;6-Bromolevamisole oxalate;S(-)-6-(4-Bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole oxalate

  • CAS NO.:62284-79-1
  • Empirical Formula: C13H13BrN2O4S
  • Molecular Weight: 373.22
  • MDL number: MFCD00070406
  • EINECS: 263-487-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
(-)-4-BROMOTETRAMISOLE OXALATE Structural

What is (-)-4-BROMOTETRAMISOLE OXALATE?

Description

Four distinct human isoenzymes of alkaline phosphatase (AP) are known: intestinal (IAP), placental (PLAP), tissue non-specific (NSAP, also known as liver/bone/kidney AP), and germ cell AP (also known as placental-like AP, PLAP-like). L-p-Bromotetramisole is a cell-permeable inhibitor of all four human AP isoenzymes (Kis =18 and 56 μM for PLAP and NSAP, respectively). While PLAP is strongly inhibited by L-p-bromotetramisole, a second AP, possibly PLAP-like, shows only partial inhibition. L-p-Bromotetramisole has been shown to inhibit a tyrosine phosphatase from Drosophila and, as a result, is also used as a tyrosine phosphatase inhibitor.

Chemical properties

white to light yellow crystal powde

The Uses of (-)-4-BROMOTETRAMISOLE OXALATE

L-p-Bromotetramisole Oxalate or (-)-p-Bromotetramisole Oxalate is a potent inhibitor of alkaline phosphatase.

What are the applications of Application

L-p-Bromotetramisole oxalate is a potent and non-specific alkaline phosphatase inhibitor that strongly activates CFTR chloride channels.

Biochem/physiol Actions

(-)-p-Bromolevamisole oxalate inhibits L-isoforms of alkaline phosphatases.

References

1) Kovach?et al. (1992),?Levamisole potentiation of fluorouracil antiproliferative activity mimicked by orthovanadate, an inhibitor of tyrosine phosphatase; J. Natl. Cancer Inst.,?84?515 2) Luo et al. (2000),?Role of protein phosphatases in the activation of CTFR (ABCC7) by genistein and bromotetramisole;?Am. J. Physiol. Cell Physiol.,?279?C108 3) Scher?et al.?(1998),?The phosphatase inhibitors, orthovanadate and levamisole, inhibit induction of erythroid differentiation and abrogate the associated inhibition of glycolysis; Int. J. Oncol.,?12?987

Properties of (-)-4-BROMOTETRAMISOLE OXALATE

Melting point: 192 °C (dec.) (lit.)
Flash point: 87℃
storage temp.  2-8°C
solubility  Soluble in Water (up to 10 mg/ml)
form  liquid
color  White
optical activity [α]25/D 104°, c = 0.5 in H2O
BRN  4944883
Stability: Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.

Safety information for (-)-4-BROMOTETRAMISOLE OXALATE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

Computed Descriptors for (-)-4-BROMOTETRAMISOLE OXALATE

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