(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE

Synonym(s):(+)-4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide

CAS NO.：56715-13-0
Empirical Formula: C14H22N2O3
Molecular Weight: 266.34
MDL number: MFCD00074917
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-21 10:59:17

(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE Structural

What is (+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE?

Description

(+)-Atenolol is an enantiomer of the β₁-adrenergic receptor (β₁-AR) antagonist (±)-atenolol . (+)-Atenolol inhibits radioligand binding to β-ARs on sarcolemma-enriched membranes (K_i = 8.61 μM). Unlike (–)-atenolol and (±)-antenolol, (+)-atenolol has no effect on blood pressure in spontaneously hypertensive rats.

The Uses of (+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE

Cardioselective β-adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic (class II).

The Uses of (+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE

Antihypertensor

The Uses of (+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE

less active enantiomer

What are the applications of Application

(R)-(+)-Atenolol is a β-adrenergic blocker

Definition

ChEBI: The (R)-enantiomer of atenolol.

References

[1] stoschitzky k, egginger g, zernig g, et al. stereoselective features of (r)- and (s)-atenolol: clinical pharmacological, pharmacokinetic, and radioligand binding studies[j]. chirality, 1993, 5(1): 15-19.

Properties of (+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE

Melting point:	148-152 °C(lit.)
Boiling point:	508.0±50.0 °C(Predicted)
Density	1.125±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >6.0 mg/mL
form	solid
pka	13.88±0.20(Predicted)
color	pale yellow
optical activity	[α]25/D +16°, c = 1 in 1 M HCl