93-14-1
Product Name:
Guaifenesin
Formula:
C10H14O4
Synonyms:
3-(o-Methoxyphenoxy)-1,2-propanediol;Glycerol guaiacolate;Guaiacol glyceryl ether;Guaifenesin
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Color/Form | Minute rhombic prisms from ether |
| Odor | SLIGHT CHARACTERISTIC ODOR |
| Taste | Slightly bitter aromatic taste |
| Boiling Point | 215 °C at 1.90E+01 mm Hg |
| Melting Point | 78.5-79 |
| Solubility | 50000 mg/L (at 25 °C) |
| LogP | 1.39 |
| Stability/Shelf Life | Stable in light and heat. |
| Kovats Retention Index | 1650 |
| Other Experimental Properties | NONHYGROSCOPIC |
SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
COMPUTED DESCRIPTORS
| Molecular Weight | 198.22 g/mol |
|---|---|
| XLogP3 | 1.4 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 5 |
| Exact Mass | 198.08920892 g/mol |
| Monoisotopic Mass | 198.08920892 g/mol |
| Topological Polar Surface Area | 58.9 Ų |
| Heavy Atom Count | 14 |
| Formal Charge | 0 |
| Complexity | 151 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Guaifenesin was originally derived from the guaiac tree and used by Native Americans for health purposes. Guaifenesin has been used in the treatment of respiratory diseases since the nineteenth century. The United States’ Food and Drug Administration (FDA) approved guaifenesin for use in overthe- counter medications in 1989. Guaifenesin is widely consumed alone and combined with antihistamines, cough suppressants, and decongestants. Guaifenesin is also a centrally acting muscle relaxant and is used routinely in combination with analgesics and sedatives in large-animal veterinary surgery.