81872-10-8
Product Name:
Zofenopril
Formula:
C22H23NO4S2
Synonyms:
α-Naphthaleneacetic acid Free acid;1-Naphthaleneacetic acid;1-Naphthaleneacetic acid, Planofix;1-Naphthylacetic acid;NAA
Inquiry
COMPUTED DESCRIPTORS
Molecular Weight | 429.6 g/mol |
---|---|
XLogP3 | 4.4 |
Hydrogen Bond Donor Count | 1 |
Hydrogen Bond Acceptor Count | 6 |
Rotatable Bond Count | 8 |
Exact Mass | 429.10685056 g/mol |
Monoisotopic Mass | 429.10685056 g/mol |
Topological Polar Surface Area | 125 Ų |
Heavy Atom Count | 29 |
Formal Charge | 0 |
Complexity | 587 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 3 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Zofenopril is a proline derivative that is 4-(phenylsulfanyl)-L-proline in which the amine proton is replaced by a (2S)-3-(benzoylsulfanyl)-2-methylpropanoyl group. A prodrug for zofenoprilat. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, an apoptosis inhibitor, a cardioprotective agent, an anticonvulsant, a prodrug and a vasodilator agent. It is a thioester, a N-acyl-L-amino acid, an aryl sulfide and a L-proline derivative. It is a conjugate acid of a zofenopril(1-).