81161-17-3
Product Name:
Esmolol hydrochloride
Formula:
C16H26ClNO4
Synonyms:
4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzenepropanoic acid methyl ester hydrochloride hydrochloride
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Color/Form | White or off-white crystalline powder |
|---|---|
| Melting Point | 85-86 °C |
| Stability/Shelf Life | Esmolol hydrochloride concentrate for injection should be stored at 15-30 °C. /Esmolol hydrochloride/ |
| Dissociation Constants | In alcohol, 350 mg/l at room temperature |
| Other Experimental Properties | Esmolol is related structurally to atenolol and metoprolol in that the drugs contain substitutents in the para position of benzene ring. /Esmolol/ |
SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
COMPUTED DESCRIPTORS
| Molecular Weight | 331.8 g/mol |
|---|---|
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 10 |
| Exact Mass | 331.1550360 g/mol |
| Monoisotopic Mass | 331.1550360 g/mol |
| Topological Polar Surface Area | 67.8 Ų |
| Heavy Atom Count | 22 |
| Formal Charge | 0 |
| Complexity | 288 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 2 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Esmolol Hydrochloride is the hydrochloride salt form of esmolol, a short and rapid-acting beta adrenergic antagonist belonging to the class II anti-arrhythmic drugs and devoid of intrinsic sympathomimetic activity. Esmolol hydrochloride competitively blocks beta-1 adrenergic receptors in cardiac muscle and reduces the contractility and cardiac rate of heart muscle, thereby decreasing cardiac output and myocardial oxygen demands. This agent also decreases sympathetic output centrally and blocks renin secretion. At higher doses, esmolol hydrochloride also blocks beta-2 receptors located in bronchial and vascular smooth muscle, thereby leading to smooth muscle relaxation.