81103-11-9

Product Name: Clarithromycin

Formula: C38H69NO13

Synonyms: 6-O-methyl erythromycin;CLM

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CHEMICAL AND PHYSICAL PROPERTIES SAFETY INFORMATION COMPUTED DESCRIPTORS PRODUCT INTRODUCTION RELATED SUPPLIERS

CHEMICAL AND PHYSICAL PROPERTIES

Physical Description	Solid
Color/Form	Colorless needles from chloroform + diisopropyl ether (1:2) ... Also reported as crystals from ethanol
Melting Point	220 dec °C
Solubility	0.33 mg/L
LogP	3.16
Optical Rotation	Specific optical rotation: -90.4 deg at 24 °C/D (c = 1 in CHCl3)
Decomposition	When heated to decomposition it emits toxic vapors of /oxides of nitrogen/.
Ionization Efficiency	Positive
Dissociation Constants	8.99
Collision Cross Section	264.2 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Other Experimental Properties	Stable at acidic pH

SAFETY INFORMATION

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..…

COMPUTED DESCRIPTORS

Molecular Weight	748.0 g/mol
XLogP3	3.2
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	8
Exact Mass	747.47689126 g/mol
Monoisotopic Mass	747.47689126 g/mol
Topological Polar Surface Area	183 Å²
Heavy Atom Count	52
Formal Charge	0
Complexity	1190
Isotope Atom Count	0
Defined Atom Stereocenter Count	18
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

PRODUCT INTRODUCTION

Description

Clarithromycin is the 6-O-methyl ether of erythromycin A. clarithromycin is a macrolide antibiotic used to treat respiratory tract, skin and soft-tissue infections. It is also used to eradicate Helicobacter pylori in treating peptic ulcer disease. It prevents bacteria from growing by interfering with their protein synthesis. Clarithromycin has a role as an antibacterial drug, a protein synthesis inhibitor, an environmental contaminant and a xenobiotic.