79794-75-5
Product Name:
Loratadine
Formula:
C22H23ClN2O2
Synonyms:
4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester;Loratadine;Loratidine
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
Physical Description | Solid |
---|---|
Color/Form | Crystals from acetonitrile |
Melting Point | 134-136 °C |
Solubility | <1 mg/ml at 25°C |
LogP | Log P= 5.20 at pH 7.4 |
Collision Cross Section | 187.4 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)] |
COMPUTED DESCRIPTORS
Molecular Weight | 382.9 g/mol |
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XLogP3 | 5.2 |
Hydrogen Bond Donor Count | 0 |
Hydrogen Bond Acceptor Count | 3 |
Rotatable Bond Count | 2 |
Exact Mass | 382.1448057 g/mol |
Monoisotopic Mass | 382.1448057 g/mol |
Topological Polar Surface Area | 42.4 Ų |
Heavy Atom Count | 27 |
Formal Charge | 0 |
Complexity | 569 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Loratadine is a H1-receptor antagonist commonly employed in the treatment of allergic disorders. It has a role as a geroprotector, a H1-receptor antagonist, an anti-allergic agent and a cholinergic antagonist. It is an ethyl ester, a N-acylpiperidine, a tertiary carboxamide, an organochlorine compound and a benzocycloheptapyridine.
RELATED SUPPLIERS
KARPSCHEM LABORATORIES PVT. LTD.
1Y
product:Loratadine
Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]
pyridin-11-ylidene)-1-piperidinecarboxylate 96%