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79794-75-5

79794-75-5 structural image
Product Name: Loratadine
Formula: C22H23ClN2O2
Synonyms: 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester;Loratadine;Loratidine
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CHEMICAL AND PHYSICAL PROPERTIES

Physical Description Solid
Color/Form Crystals from acetonitrile
Melting Point 134-136 °C
Solubility <1 mg/ml at 25°C
LogP Log P= 5.20 at pH 7.4
Collision Cross Section 187.4 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]

COMPUTED DESCRIPTORS

Molecular Weight 382.9 g/mol
XLogP3 5.2
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 2
Exact Mass 382.1448057 g/mol
Monoisotopic Mass 382.1448057 g/mol
Topological Polar Surface Area 42.4 Ų
Heavy Atom Count 27
Formal Charge 0
Complexity 569
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Loratadine is a H1-receptor antagonist commonly employed in the treatment of allergic disorders. It has a role as a geroprotector, a H1-receptor antagonist, an anti-allergic agent and a cholinergic antagonist. It is an ethyl ester, a N-acylpiperidine, a tertiary carboxamide, an organochlorine compound and a benzocycloheptapyridine.

RELATED SUPPLIERS

TAGOOR LABORATORIES PVT LTD

2Y
product:79794-75-5 Loratadine BP/ Ph. Eur /USP >98%

GLP Pharma Standards

2Y
product:79794-75-5 Loratadine API 98%

KARPSCHEM LABORATORIES PVT. LTD.

1Y
product:Loratadine Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b] pyridin-11-ylidene)-1-piperidinecarboxylate 96%

Ions Pharma

1Y
product:Loratadine 98%

Glenmark Pharmaceuticals Limited

1Y
product:79794-75-5 98%

Hetero Drugs Limited

1Y
product:Loratadine 98%

Sam Fine O Chem Limited

1Y
product:Loratadine 79794-75-5 98%

Vanquest Pharma Pvt Ltd

1Y
product:79794-75-5 Loratadine 98%

Dolphin Chem

1Y
product:79794-75-5 98%
All suppliers(25)