76824-35-6
Product Name:
Famotidine
Formula:
C8H15N7O2S3
Synonyms:
{3-[((2-((Aminoiminomethyl)amino)-4-thiazolyl)methyl)thio]-N′-(aminosulfonyl)propaneimidamide};N′-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine;Famotidine
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CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Color/Form | White to pale yellow crystals |
| Melting Point | 163-164 °C |
| Solubility | Solubility at 20 °C (% w/v): 80 in DMF; 50 in acetic acid; 0.3 in methanol; 0.1 in water; <0.01 in ethanol, ethyl acetate, chloroform |
| LogP | logP = -0.57, measured at pH 9.2 |
| Chemical Classes | Other Uses -> Pharmaceuticals |
SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H303:Acute toxicity,oral |
| Precautionary Statement Codes |
P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P403:Store in a well-ventilated place. |
COMPUTED DESCRIPTORS
| Molecular Weight | 337.5 g/mol |
|---|---|
| XLogP3 | -0.6 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 7 |
| Exact Mass | 337.04493627 g/mol |
| Monoisotopic Mass | 337.04493627 g/mol |
| Topological Polar Surface Area | 238 Ų |
| Heavy Atom Count | 20 |
| Formal Charge | 0 |
| Complexity | 469 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 1 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Famotidine is a compound that has been extensively studied in the context of its interaction with histamine H2 receptors. In research environments, the focus on Famotidine often centers on the elucidation of receptor-ligand interactions within the gastrointestinal system. Investigations into the mechanism of action of Famotidine involve the exploration of how it binds to and influences the activity of H2 receptors, which are implicated in the regulation of gastric acid secretion.