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74103-06-3

74103-06-3 structural image
Product Name: Ketorolac
Formula: C15H13NO3
Synonyms: (-)-Ketorolac;(1S)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid;(S)-Ketorolac
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CHEMICAL AND PHYSICAL PROPERTIES

Physical Description Solid
Melting Point 162-165 °C (tromethamine salt)
Solubility 200 g/l (tromethamine salt)
LogP 2.1
Dissociation Constants 3.49

SAFETY INFORMATION

Signal word Warning
Pictogram(s)

Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H332:Acute toxicity,inhalation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

COMPUTED DESCRIPTORS

Molecular Weight 255.27 g/mol
XLogP3 1.9
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 3
Exact Mass 255.08954328 g/mol
Monoisotopic Mass 255.08954328 g/mol
Topological Polar Surface Area 59.3 Ų
Heavy Atom Count 19
Formal Charge 0
Complexity 376
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Ketorolac is a racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure. It has a role as a cyclooxygenase 2 inhibitor, a cyclooxygenase 1 inhibitor, a non-steroidal anti-inflammatory drug and an analgesic. It contains a (R)-ketorolac and a (S)-ketorolac. It is a conjugate acid of a ketorolac(1-).

RELATED SUPPLIERS

Sanpra Synthesis Private Limited

2Y
product:5-BENZOYL-2,3-DIHYDRO-1H-PYRROLIZINE-1-CARBOXYLIC ACID 74103-06-3

Vepan Pharmatech Pvt Ltd

1Y
product:Ketorolac 98%

HRV Global Life Sciences

1Y
product:Ketorolac 74103-06-3 99%

Chempifine Chemicals

1Y
product:74103-06-3 Ketorolac 98%

Ralington Pharma

1Y
product:74103-06-3 98%

Glyra Health Care Pvt Ltd

product:Ketorolac 99%

Ratnagene lifescience Pvt Ltd

1Y
product:74103-06-3 Ketorolac 98%

SETV ASRV LLP

1Y
product:5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic Acid 95-99%

CSD Labs

Hyderabad
product:Ketorolac
All suppliers(9)