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72509-76-3

72509-76-3 structural image
Product Name: Felodipine
Formula: C18H19Cl2NO4
Synonyms: 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester;Plendil
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CHEMICAL AND PHYSICAL PROPERTIES

Physical Description Solid
Melting Point 145 °C
Solubility 19.7 mg/L
LogP 3.86
Caco2 Permeability -4.64
Kovats Retention Index 2718.2 2678

SAFETY INFORMATION

Signal word Warning
Pictogram(s)

Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral

COMPUTED DESCRIPTORS

Molecular Weight 384.2 g/mol
XLogP3 3.9
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 6
Exact Mass 383.0691135 g/mol
Monoisotopic Mass 383.0691135 g/mol
Topological Polar Surface Area 64.6 Ų
Heavy Atom Count 25
Formal Charge 0
Complexity 614
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Felodipine is the mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris. It has a role as a calcium channel blocker, an antihypertensive agent, a vasodilator agent and an anti-arrhythmia drug. It is a dihydropyridine, a dichlorobenzene, an ethyl ester and a methyl ester.

RELATED SUPPLIERS

Alembic Pharmaceuticals Limited

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product:72509-76-3 / 86189-69-7 98%

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product:Felodipine 98%

Rivashaa Agrotech Biopharma Pvt. Ltd.

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Ebenezer Industries

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Narmada Organics

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Vishrudh laboratories pvt ltd

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product:Felodipine 72509-76-3 / 86189-69-7 98%

Cipla Ltd.

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All suppliers(10)