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723-46-6

723-46-6 structural image
Product Name: Sulfamethoxazole
Formula: C10H11N3O3S
Synonyms: N1-(5-Methylisoxazol-3-yl)sulfanilamide;4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide
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SAFETY INFORMATION

Signal word Warning
Pictogram(s)

Exclamation Mark
Irritant
GHS07

Health Hazard
GHS08
GHS Hazard Statements H317:Sensitisation, Skin
Precautionary Statement Codes P201:Obtain special instructions before use.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P308+P313:IF exposed or concerned: Get medical advice/attention.

PRODUCT INTRODUCTION

Description

Sulfamethoxazole (SMX) is a sulfonamide that works sequentially and synergistically with trimethoprim (TMP) to inhibit bacterial folate synthesis. SMX inhibits dihydrofolic acid and stops the formation of tetrahydrofolic acid (THF), whereas TMP prevents the formation of THF by binding to dihydrofolate reductase. THF is necessary for bacterial DNA synthesis. The synergistic effects of using SMX with TMP (SMX-TMP) enhance the bactericidal effect of both agents.

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