723-46-6
Product Name:
Sulfamethoxazole
Formula:
C10H11N3O3S
Synonyms:
N1-(5-Methylisoxazol-3-yl)sulfanilamide;4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide
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SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H317:Sensitisation, Skin |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P308+P313:IF exposed or concerned: Get medical advice/attention. |
PRODUCT INTRODUCTION
Description
Sulfamethoxazole (SMX) is a sulfonamide that works sequentially and synergistically with trimethoprim (TMP) to inhibit bacterial folate synthesis. SMX inhibits dihydrofolic acid and stops the formation of tetrahydrofolic acid (THF), whereas TMP prevents the formation of THF by binding to dihydrofolate reductase. THF is necessary for bacterial DNA synthesis. The synergistic effects of using SMX with TMP (SMX-TMP) enhance the bactericidal effect of both agents.