CHEMICAL AND PHYSICAL PROPERTIES
| Color/Form | CRYSTALS |
|---|---|
| Odor | LITTLE OR NO ODOR |
| Taste | BITTER TASTE |
| Melting Point | 120 °C |
| Solubility | PRACTICALLY INSOL IN WATER |
| Stability/Shelf Life | STABLE IN AIR & LIGHT |
| Decomposition | When heated to decomp it emits toxic fumes of oxides of nitrogen. |
| pH | AQ SOLN ALKALINE TO LITMUS |
| Dissociation Constants | pKa= 2.4 |
| Collision Cross Section | 155 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)] |
| Kovats Retention Index | 2135 2152 2125 2094 2158 2119 2115 2117 2103 2115 2125 2133 2125 2155 2125 2125 2129 2130 2144 2142 2150 2130 2127 2130 2130 2130 2135 2162 2165 2144 2129.6 2125 2125 2130 2096 2109 2115 2117 2119 2119 2132 2139 2153 2105 2165 2125 2133.6 2154.3 2118 2130 2130 2139 2180 2123 2123 |
| Other Experimental Properties | CRYSTALS; MP: 255-265 °C; SOLUBILITY: SOL IN ETHER, ETHANOL; PRACTICALLY INSOL IN WATER /METHAQUALONE HYDROCHLORIDE/ |
SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Flame Flammables GHS02  Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H225:Flammable liquids H370:Specific target organ toxicity, single exposure |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P311:Call a POISON CENTER or doctor/physician. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
COMPUTED DESCRIPTORS
| Molecular Weight | 250.29 g/mol |
|---|---|
| XLogP3 | 2.5 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 1 |
| Exact Mass | 250.110613074 g/mol |
| Monoisotopic Mass | 250.110613074 g/mol |
| Topological Polar Surface Area | 32.7 Ų |
| Heavy Atom Count | 19 |
| Formal Charge | 0 |
| Complexity | 390 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Methaqualone is a member of the class of quinazolines that is quinazolin-4-one substituted at positions 2 and 3 by methyl and o-tolyl groups respectively. A depressant that increases the activity of the GABA receptors in the brain and nervous system, it is used as a sedative and hypnotic medication. It became popular as a recreational drug and club drug in the late 1960s and 1970s. It has a role as a GABA agonist and a sedative.