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68521-88-0

68521-88-0 structural image
Product Name: Angiotensin II human acetate
Formula: C52H75N13O14
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COMPUTED DESCRIPTORS

Molecular Weight 1106.2 g/mol
Hydrogen Bond Donor Count 14
Hydrogen Bond Acceptor Count 17
Rotatable Bond Count 29
Exact Mass 1105.55564412 g/mol
Monoisotopic Mass 1105.55564412 g/mol
Topological Polar Surface Area 446 Ų
Heavy Atom Count 79
Formal Charge 0
Complexity 2010
Isotope Atom Count 0
Defined Atom Stereocenter Count 9
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 2
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Angiotensin II Acetate is the acetate salt form of therapeutic angiotensin II, a synthetic form of the endogenous angiotensin II, a peptide hormone of the renin-angiotensin-aldosterone system (RAAS) that causes vasoconstriction and an increase in blood pressure, that may be used for the treatment of septic or other distributive shock. Upon administration, therapeutic angiotensin II binds to angiotensin II type 1 receptor on vascular smooth muscle cells which leads to Ca2+/calmodulin-dependent phosphorylation of myosin. This causes smooth muscle contraction and results in vasoconstriction and an increase in blood pressure. Therapeutic angiotensin II also increases blood pressure by stimulating the release of the steroid hormone aldosterone, which regulates the renal absorption of water and sodium.

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