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66085-59-4

66085-59-4 structural image
Product Name: Nimodipine
Formula: C21H26N2O7
Synonyms: 1,4-Dihydro-2,6-dimethyl-4-(3ʹ-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl-1-methylethyl Ester;1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester;Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate;Nimodipine;Nimodipine - CAS 66085-59-4 - Calbiochem
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CHEMICAL AND PHYSICAL PROPERTIES

Physical Description Solid
Melting Point 125 °C
Solubility 1.20e-02 g/L
LogP 3.05
Collision Cross Section 197.8 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]
Kovats Retention Index 2840.44

SAFETY INFORMATION

Signal word Warning
Pictogram(s)

Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501:Dispose of contents/container to..…

COMPUTED DESCRIPTORS

Molecular Weight 418.4 g/mol
XLogP3 3.1
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 8
Rotatable Bond Count 9
Exact Mass 418.17400117 g/mol
Monoisotopic Mass 418.17400117 g/mol
Topological Polar Surface Area 120 Ų
Heavy Atom Count 30
Formal Charge 0
Complexity 736
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Nimodipine is a dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm. It has a role as an antihypertensive agent, a calcium channel blocker, a vasodilator agent and a cardiovascular drug. It is a dihydropyridine, a C-nitro compound, a diester, a member of dicarboxylic acids and O-substituted derivatives, a 2-methoxyethyl ester and an isopropyl ester.

RELATED SUPPLIERS

GLP Pharma Standards

2Y
product:66085-59-4 98%

Vivimed Labs Ltd

1Y
product:Nimodipine 98%

Rivashaa Agrotech Biopharma Pvt. Ltd.

1Y
product:Nimodipine 66085-59-4 98%

Biophore India Pharmaceuticals Pvt Ltd

1Y
product:66085-59-4 Nimodipine 98%

SETV ASRV LLP

1Y
product:66085-59-4 NIMODIPINE 95-99%
All suppliers(5)