CHEMICAL AND PHYSICAL PROPERTIES
Solubility | Water > 16 (mg/mL) |
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Optical Rotation | (c = 1.2, H2O) [a]25D = 121.5 ± 2 |
COMPUTED DESCRIPTORS
Molecular Weight | 244.20 g/mol |
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XLogP3 | -2.2 |
Hydrogen Bond Donor Count | 4 |
Hydrogen Bond Acceptor Count | 5 |
Rotatable Bond Count | 2 |
Exact Mass | 244.08076950 g/mol |
Monoisotopic Mass | 244.08076950 g/mol |
Topological Polar Surface Area | 141 Ų |
Heavy Atom Count | 17 |
Formal Charge | 0 |
Complexity | 384 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 4 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Fazarabine is an N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-arabinofuranosyl residue via an N-glycosidic linkage. A synthetic analogue of cytosine arabinoside and 5-azacytidine that incorporates structural features of both compounds, it shows good activity against a variety of transplanted tumors. It has a role as an antineoplastic agent. It is a N-glycosyl-1,3,5-triazine and a nucleoside analogue. It is functionally related to a beta-D-arabinofuranose.