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65886-71-7

65886-71-7 structural image
Product Name: Fazarabine
Formula: C8H12N4O5
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CHEMICAL AND PHYSICAL PROPERTIES

Solubility Water > 16 (mg/mL)
Optical Rotation (c = 1.2, H2O) [a]25D = 121.5 ± 2

COMPUTED DESCRIPTORS

Molecular Weight 244.20 g/mol
XLogP3 -2.2
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 2
Exact Mass 244.08076950 g/mol
Monoisotopic Mass 244.08076950 g/mol
Topological Polar Surface Area 141 Ų
Heavy Atom Count 17
Formal Charge 0
Complexity 384
Isotope Atom Count 0
Defined Atom Stereocenter Count 4
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Fazarabine is an N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-arabinofuranosyl residue via an N-glycosidic linkage. A synthetic analogue of cytosine arabinoside and 5-azacytidine that incorporates structural features of both compounds, it shows good activity against a variety of transplanted tumors. It has a role as an antineoplastic agent. It is a N-glycosyl-1,3,5-triazine and a nucleoside analogue. It is functionally related to a beta-D-arabinofuranose.