CHEMICAL AND PHYSICAL PROPERTIES
Physical Description | Solid |
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Melting Point | ~159°C with decomposition (nitrate salt) |
Solubility | Nitrate salt: 0.26 mg/ml (practically insoluble) |
LogP | 6.7 |
Collision Cross Section | 186.5 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards] |
COMPUTED DESCRIPTORS
Molecular Weight | 411.8 g/mol |
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XLogP3 | 6.4 |
Hydrogen Bond Donor Count | 0 |
Hydrogen Bond Acceptor Count | 2 |
Rotatable Bond Count | 7 |
Exact Mass | 410.017803 g/mol |
Monoisotopic Mass | 410.017803 g/mol |
Topological Polar Surface Area | 43.1 Ų |
Heavy Atom Count | 25 |
Formal Charge | 0 |
Complexity | 383 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 1 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Butoconazole is a member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to the nitrogen is substituted by a 4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)sulfanyl]butyl group. An antifungal agent, it is used as its nitrate salt in gynaecology for treatment of vulvovaginal infections caused by Candida species, particularly Candida albicans. It is a member of imidazoles, an aryl sulfide, a dichlorobenzene, a member of monochlorobenzenes, an imidazole antifungal drug and a conazole antifungal drug. It is a conjugate base of a butoconazole(1+).