64-77-7
Product Name:
TOLBUTAMIDE
Formula:
C12H18N2O3S
Synonyms:
N-[(Butylamino)carbonyl]-4-methylbenzenesulfonamide;1-Butyl-3-(4-methylphenylsulfonyl)urea;Tolbutamide
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Tolbutamide appears as white crystals. (NTP, 1992) |
|---|---|
| Color/Form | WHITE OR PRACTICALLY WHITE CRYSTALLINE POWDER |
| Melting Point | 262 to 264 °F (NTP, 1992) |
| Solubility | >40.6 [ug/mL] (The mean of the results at pH 7.4) |
| Density | 1.245 at 77 °F (NTP, 1992) - Denser than water; will sink |
| LogP | 2.34 |
| LogS | -3.39 |
| Dissociation Constants | 5.16 |
| Collision Cross Section | 163 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)] |
| Kovats Retention Index | 1670 1648.8 1683 |
| Other Experimental Properties | PRACTICALLY ODORLESS; HAS SLIGHTLY BITTER TASTE /SODIUM SALT/ |
SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H317:Sensitisation, Skin |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P321:Specific treatment (see … on this label). P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. |
COMPUTED DESCRIPTORS
| Molecular Weight | 270.35 g/mol |
|---|---|
| XLogP3 | 2.3 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 5 |
| Exact Mass | 270.10381361 g/mol |
| Monoisotopic Mass | 270.10381361 g/mol |
| Topological Polar Surface Area | 83.6 Ų |
| Heavy Atom Count | 18 |
| Formal Charge | 0 |
| Complexity | 354 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Tolbutamide appears as white crystals. (NTP, 1992)