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572924-54-0

572924-54-0 structural image
Product Name: 42-(Dimethylphosphinate)rapamycin
Formula: C53H84NO14P
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COMPUTED DESCRIPTORS

Molecular Weight 990.2 g/mol
XLogP3 5.9
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 14
Rotatable Bond Count 8
Exact Mass 989.56294335 g/mol
Monoisotopic Mass 989.56294335 g/mol
Topological Polar Surface Area 202 Ų
Heavy Atom Count 69
Formal Charge 0
Complexity 1940
Isotope Atom Count 0
Defined Atom Stereocenter Count 15
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 4
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Ridaforolimus is a small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with potential antitumor activity. Ridaforolimus binds to and inhibits the mammalian target of rapamycin (mTOR), which may result in cell cycle arrest and, consequently, the inhibition of tumor cell growth and proliferation. Upregulated in some tumors, mTOR is a serine/threonine kinase involved in regulating cellular proliferation, motility, and survival that is located downstream of the PI3K/Akt signaling pathway.