57-83-0
Product Name:
Progesterone
Formula:
C21H30O2
Synonyms:
Lutein;Progesterone;Xanthophyll;4-Pregnene-3,20-dione;Progesterone - CAS 57-83-0 - Calbiochem
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Progesterone is a white powder. Melting point 121 °C. Stable in air. Insoluble in water. A female sex hormone. Low toxicity. |
|---|---|
| Color/Form | Prisms |
| Odor | Odorless |
| Boiling Point | 394.13°C (rough estimate) |
| Melting Point | 250 to 252 °F (NTP, 1992) |
| Solubility | less than 1 mg/mL at 66 °F (NTP, 1992) |
| Density | 1.171 at 68 °F (NTP, 1992) - Denser than water; will sink |
| LogP | 3.87 |
| LogS | -4.43 |
| Stability/Shelf Life | Progesterone is stable when exposed to air. The drug should be stored in tight, light-resistant containers. |
| Optical Rotation | Specific optical rotation: +192 /alpha-Progesterone/ |
| Decomposition | When heated to decomposition, it emits acrid smoke and irritating fumes. |
| Ionization Efficiency | Positive |
| Dissociation Constants | Strongest acidic: , Strongest basic: 18.92, -4.8 |
| Collision Cross Section | 181.2 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)] |
| Kovats Retention Index | 2793 2793 |
| Other Experimental Properties | /both forms have/ equal physiologic activity and are readily interconverted |
SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Health Hazard GHS08 |
| GHS Hazard Statements |
H351:Carcinogenicity H362:Reproductive toxicity, effects on or via lactation |
| Precautionary Statement Codes |
P202:Do not handle until all safety precautions have been read and understood. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P263:Avoid contact during pregnancy/while nursing. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P308+P313:IF exposed or concerned: Get medical advice/attention. |
COMPUTED DESCRIPTORS
| Molecular Weight | 314.5 g/mol |
|---|---|
| XLogP3 | 3.9 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 1 |
| Exact Mass | 314.224580195 g/mol |
| Monoisotopic Mass | 314.224580195 g/mol |
| Topological Polar Surface Area | 34.1 Ų |
| Heavy Atom Count | 23 |
| Formal Charge | 0 |
| Complexity | 589 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 6 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Progesterone is a white powder. Melting point 121 °C. Stable in air. Insoluble in water. A female sex hormone. Low toxicity.