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54063-53-5

54063-53-5 structural image
Product Name: Propafenone
Formula: C21H27NO3
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CHEMICAL AND PHYSICAL PROPERTIES

Physical Description Solid
Solubility Slightly soluble
LogP 3.2
Decomposition When heated to decomposition, material emits toxic fumes of NOx and HCl.
Dissociation Constants 9.27
Collision Cross Section 178.5 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]
Other Experimental Properties MW: 377.90. Fine white crystals; slightly bitter taste. Soluble in basic lower aliphatic alcohols, carbon tetrachloride, hot water; slightly soluble in cold water. Insoluble in ether /Propafenone hydrochloride/

SAFETY INFORMATION

Signal word Warning
Pictogram(s)

Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

COMPUTED DESCRIPTORS

Molecular Weight 341.4 g/mol
XLogP3 3.3
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 11
Exact Mass 341.19909372 g/mol
Monoisotopic Mass 341.19909372 g/mol
Topological Polar Surface Area 58.6 Ų
Heavy Atom Count 25
Formal Charge 0
Complexity 368
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Propafenone is an aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias. It has a role as an anti-arrhythmia drug. It is a secondary amino compound, a secondary alcohol and an aromatic ketone. It is a conjugate base of a propafenone(1+).

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All suppliers(3)