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529488-28-6

529488-28-6 structural image
Product Name: Genz644282
Formula: C22H21N3O5
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COMPUTED DESCRIPTORS

Molecular Weight 407.4 g/mol
XLogP3 2.2
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 7
Rotatable Bond Count 5
Exact Mass 407.14812078 g/mol
Monoisotopic Mass 407.14812078 g/mol
Topological Polar Surface Area 82.2 Ų
Heavy Atom Count 30
Formal Charge 0
Complexity 636
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Topoisomerase I Inhibitor Genz-644282 is a non-camptothecin inhibitor of topoisomerase I with potential antineoplastic activity. Topoisomerase I inhibitor Genz-644282 binds to and inhibits the enzyme topoisomerase I, which may result in the inhibition of repair of single-strand DNA breaks, DNA replication, and tumor cell growth in susceptible tumor cell populations.