CHEMICAL AND PHYSICAL PROPERTIES
Physical Description | Solid |
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Color/Form | Yellow crystalline powder |
Melting Point | 235 °C |
Solubility | <1 mg/mL |
LogP | 3.8 |
Stability/Shelf Life | Three yr at ambient temp not exceeding 25 °C, protected from light. |
Decomposition | When heated to decomposition it emits very toxic fumes of /nitric oxides & sulfur oxides/ |
Collision Cross Section | 193.1 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards] |
Other Experimental Properties | Mol wt 429.93. Crystals, mp 197-199 °C /Hydrochloride/ |
SAFETY INFORMATION
Signal word | Warning |
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Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H227:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P370+P378:In case of fire: Use … for extinction. P403+P235:Store in a well-ventilated place. Keep cool. |
COMPUTED DESCRIPTORS
Molecular Weight | 393.5 g/mol |
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XLogP3 | 4 |
Hydrogen Bond Donor Count | 2 |
Hydrogen Bond Acceptor Count | 6 |
Rotatable Bond Count | 5 |
Exact Mass | 393.11471265 g/mol |
Monoisotopic Mass | 393.11471265 g/mol |
Topological Polar Surface Area | 88.7 Ų |
Heavy Atom Count | 28 |
Formal Charge | 0 |
Complexity | 601 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Amsacrine is a sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity. It has a role as an antineoplastic agent and an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor. It is a sulfonamide, a member of acridines and an aromatic ether.