51-21-8
Product Name:
5-Fluorouracil
Formula:
C4H3FN2O2
Synonyms:
5-FU;5-Fluorouracil;5-Fluorouracil - CAS 51-21-8 - Calbiochem;2,4-Dihydroxy-5-fluoropyrimidine;5-Fluoro-2,4(1H,3H)-pyrimidinedione
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Fluorouracil is a white to nearly white crystalline powder; practically odorless. Used as an anti neoplastic drug, chemosterilant for insects. (EPA, 1998) |
|---|---|
| Color/Form | White to practically white crystalline powder |
| Odor | PRACTICALLY ODORLESS |
| Boiling Point | Decomposes at 282-283 °C; sublimes (0.1 mm): 190-200 °C |
| Melting Point | Decomposes at 540-541 °F (EPA, 1998) |
| Solubility | less than 1 mg/mL at 66 °F (NTP, 1992) |
| LogP | -0.89 |
| LogS | -1.07 |
| Stability/Shelf Life | Stable when exposed to air. |
| Decomposition | When heated to decomposition it emits very toxic fumes of /hydrogen fluoride and nitrogen oxides/. |
| Dissociation Constants | 8.02 |
SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H351:Carcinogenicity |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
COMPUTED DESCRIPTORS
| Molecular Weight | 130.08 g/mol |
|---|---|
| XLogP3 | -0.9 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 0 |
| Exact Mass | 130.01785550 g/mol |
| Monoisotopic Mass | 130.01785550 g/mol |
| Topological Polar Surface Area | 58.2 Ų |
| Heavy Atom Count | 9 |
| Formal Charge | 0 |
| Complexity | 199 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
Description
5-Fluorouracilis, also called 5FU. It is used to treat many types of cancer. Fluorouracil is a white to nearly white crystalline powder, practically odorless. Used as an anti neoplastic drug, chemosterilant for insects.