50-63-5
Product Name:
Chloroquine diphosphate
Formula:
C18H32ClN3O8P2
Synonyms:
N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt;Chloroquine diphosphate salt;N4-(7-chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine diphosphate
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SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
PRODUCT INTRODUCTION
Description
Chloroquine diphosphate is an anti-malarial (Plasmodium) drug and a member of the quinolone family of drugs. It inhibits cell growth and induces cell death in a variety of cancer cell lines; inhibits cell proliferation and viability and induces apoptosis in 4T1 mouse breast cancer cells in vitro. It has anti-metastatic activity and also inhibits autophagy. Blocks receptor-mediated endocytosis of mannose-sugar conjugates by macrophages. Inhibits SARS-CoV-2 infection in vitro (EC50 = 1.13 μM). Chloroquine enhances adeno-associated virus gene transduction in vivo and in vitro and enhances non-viral gene transfection in breast cancer cells.