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467214-21-7

467214-21-7 structural image
Product Name: 17-DMAG
Formula: C32H49ClN4O8
Synonyms: 17-DMAG - CAS 467214-21-7 - Calbiochem;NSC 707545, 17-Desmethoxy-17-N,N-dimethylaminoethylamino-geldanamycin, HCl, 17-N,N-Dimethylaminoethylamino-17-demethoxy-geldanamycin, HCl, 17DMAG
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COMPUTED DESCRIPTORS

Molecular Weight 653.2 g/mol
Hydrogen Bond Donor Count 5
Hydrogen Bond Acceptor Count 10
Rotatable Bond Count 8
Exact Mass 652.3238922 g/mol
Monoisotopic Mass 652.3238922 g/mol
Topological Polar Surface Area 170 Ų
Heavy Atom Count 45
Formal Charge 0
Complexity 1230
Isotope Atom Count 0
Defined Atom Stereocenter Count 6
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 3
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 2
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Alvespimycin Hydrochloride is the hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.