442633-00-3
Product Name:
2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
Formula:
C18H17FN2O
Synonyms:
;2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-benzamide;
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COMPUTED DESCRIPTORS
| Molecular Weight | 296.3 g/mol |
|---|---|
| XLogP3 | 3.8 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 4 |
| Exact Mass | 296.13249133 g/mol |
| Monoisotopic Mass | 296.13249133 g/mol |
| Topological Polar Surface Area | 44.9 Ų |
| Heavy Atom Count | 22 |
| Formal Charge | 0 |
| Complexity | 389 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
CK-666 is a member of the class of indoles that is 2-methyltryptamine in which a hydrogen attached to the primary amino group has been replaced by a 2-fluorobenzoyl group. It is a cell-permeable inhibitor of actin assembly mediated by actin-related protein Arp2/3 complex which works by binding to Arp2/3 complex, stabilising the inactive state of the complex and preventing its movement into the active conformation. It has a role as an actin polymerisation inhibitor. It is a member of indoles, an organofluorine compound and a member of benzamides.