41575-94-4
Product Name:
Carboplatin
Formula:
C6H12N2O4Pt
Synonyms:
cis-Diamine[1,1-cyclobutanedicarboxylato]platinum(II), JM-8, Paraplatin;cis-Diammine(1,1-cyclobutanedicarboxylato) platinum;Carboplatin;Carboplatin - CAS 41575-94-4 - Calbiochem
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Color/Form | White crystals |
|---|---|
| Solubility | Sol in water |
| Stability/Shelf Life | The manufacturer states that constituted solns are stable for 8 hr at a room temp not exceeding 25 °C. However, other information indicates that the drug may be stable for a much longer time. At a concn of 15 mg/ml in sterile water for injection or at concns of 2 & 0.5 mg/ml in dextrose 5% in water, no decomp occurs in 24 hr at 22-25 °C. Aqueous solns of 10 mg/ml prefilled into plastic syringes exhibited no decomp in 5 days at 4 °C & only a 3% loss in 24 hr at 37 °C. |
| Decomposition | When heated to decomposition it emits toxic fumes of /nitrogen oxides/. |
| Other Experimental Properties | Incompatible with aluminum |
SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H317:Sensitisation, Skin H334:Sensitisation, respiratory H340:Germ cell mutagenicity H360:Reproductive toxicity |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P308+P313:IF exposed or concerned: Get medical advice/attention. |
COMPUTED DESCRIPTORS
| Molecular Weight | 371.25 g/mol |
|---|---|
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 0 |
| Exact Mass | 371.044501 g/mol |
| Monoisotopic Mass | 371.044501 g/mol |
| Topological Polar Surface Area | 76.6 Ų |
| Heavy Atom Count | 13 |
| Formal Charge | 0 |
| Complexity | 177 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 4 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Carboplatin is an intravenously administered platinum coordination complex and alkylating agent which is used as a chemotherapeutic agent for the treatment of various cancers, mainly ovarian, head and neck and lung cancers. Carboplatin therapy is associated with a low rate of transient serum aminotransferase elevations and with rare instances of clinically apparent liver injury.