414864-00-9
Product Name:
Belinostat (PXD101)
Formula:
C15H14N2O4S
Synonyms:
(2E)-N-Hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide;(2E)-N-Hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propenamide;(E)-N-Hydroxy-3-(3-(N-phenylsulfamoyl)phenyl)acrylamide;
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CHEMICAL AND PHYSICAL PROPERTIES
| Solubility | 0.14 mg/mL |
|---|---|
| Dissociation Constants | 7.87 and 8.71 by potentiometry |
COMPUTED DESCRIPTORS
| Molecular Weight | 318.3 g/mol |
|---|---|
| XLogP3 | 1.7 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 5 |
| Exact Mass | 318.06742811 g/mol |
| Monoisotopic Mass | 318.06742811 g/mol |
| Topological Polar Surface Area | 104 Ų |
| Heavy Atom Count | 22 |
| Formal Charge | 0 |
| Complexity | 492 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 1 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Belinostat is a hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. It has a role as an antineoplastic agent and an EC 3.5.1.98 (histone deacetylase) inhibitor. It is a hydroxamic acid, a sulfonamide and an olefinic compound.