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3902-71-4

3902-71-4 structural image
Product Name: TRIOXSALEN
Formula: C14H12O3
Synonyms: 2,5,9-Trimethylfuro[3,2-g]benzopyran-7-one;4,5′,8-Trimethylpsoralen;TMP;Trioxsalen;Trisoralen
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CHEMICAL AND PHYSICAL PROPERTIES

Physical Description Solid
Melting Point 234.5 °C
Collision Cross Section 147.4 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Kovats Retention Index 2155 2155

SAFETY INFORMATION

Signal word Danger
Pictogram(s)

Corrosion
Corrosives
GHS05

Exclamation Mark
Irritant
GHS07

Health Hazard
GHS08
GHS Hazard Statements H314:Skin corrosion/irritation
H341:Germ cell mutagenicity
Precautionary Statement Codes P202:Do not handle until all safety precautions have been read and understood.
P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

COMPUTED DESCRIPTORS

Molecular Weight 228.24 g/mol
XLogP3 3
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 0
Exact Mass 228.078644241 g/mol
Monoisotopic Mass 228.078644241 g/mol
Topological Polar Surface Area 39.4 Ų
Heavy Atom Count 17
Formal Charge 0
Complexity 374
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Trioxsalen is 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis. It has a role as a photosensitizing agent and a dermatologic drug.

RELATED SUPPLIERS

Himpharm

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product:3902-71-4 98%

Shimoga Chemicals

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product:Trioxsalen 98%

Namiex Chemicals Private Limited

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Himpharm

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product:Trioxsalen
All suppliers(4)