CHEMICAL AND PHYSICAL PROPERTIES
Color/Form | White or almost white powder |
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Odor | Odorless |
Taste | Bitter |
Melting Point | 163-164 °C |
Solubility | >44.4 [ug/mL] (The mean of the results at pH 7.4) |
LogP | log Kow = -0.45 @ pH 2.0 |
Stability/Shelf Life | IT IS STABLE TO HEAT, UNSTABLE TO LIGHT. /HYDROCHLORIDE/ |
Decomposition | When heated to decomposition it emits toxic fumes of oxides of nitrogen. |
Dissociation Constants | pKa = 9.45 |
Other Experimental Properties | Intense mass spectral peaks: 72 m/z, 100 m/z, 144 m/z, 259 m/z /Propranolol/ |
COMPUTED DESCRIPTORS
Molecular Weight | 295.80 g/mol |
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Hydrogen Bond Donor Count | 3 |
Hydrogen Bond Acceptor Count | 3 |
Rotatable Bond Count | 6 |
Exact Mass | 295.1339066 g/mol |
Monoisotopic Mass | 295.1339066 g/mol |
Topological Polar Surface Area | 41.5 Ų |
Heavy Atom Count | 20 |
Formal Charge | 0 |
Complexity | 257 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 1 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 2 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Propranolol Hydrochloride is the hydrochloride form of propranolol, a synthetic beta-adrenergic receptor blocker with antianginal, antiarrhythmic, and antihypertensive properties. Propranolol competitively antagonizes beta-adrenergic receptors, thereby inhibiting beta-adrenergic reactions, such as vasodilation, and negative chronotropic and inotropic effects.