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3239-44-9

3239-44-9 structural image
Product Name: (+)-FENFLURAMINE HYDROCHLORIDE
Formula: C12H16F3N
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CHEMICAL AND PHYSICAL PROPERTIES

Physical Description Solid
Solubility 2.15e-02 g/L
LogP 3.5
Optical Rotation Specific optical rotation = +9.5 deg at 25 °C/D ( c = 8 in ethanol)

COMPUTED DESCRIPTORS

Molecular Weight 231.26 g/mol
XLogP3 3.4
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 4
Exact Mass 231.12348400 g/mol
Monoisotopic Mass 231.12348400 g/mol
Topological Polar Surface Area 12 Ų
Heavy Atom Count 16
Formal Charge 0
Complexity 203
Isotope Atom Count 0
Defined Atom Stereocenter Count 1
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

(S)-fenfluramine is the S-enantiomer of fenfluramine. It stimulates the release of serotonin and selectively inhibits its reuptake, but unlike fenfluramine it does not possess catecholamine agonist activity. It was formerly given by mouth as the hydrochloride in the treatment of obesity, but, like fenfluramine, was withdrawn wolrdwide following reports of valvular heart defects. It has a role as an appetite depressant, a serotonergic agonist and a serotonin uptake inhibitor. It is an enantiomer of a (R)-fenfluramine.