CHEMICAL AND PHYSICAL PROPERTIES
| Boiling Point | 642.7 |
|---|---|
| Melting Point | 113-115 |
| Solubility | 13.4 mg/mL in distilled water at 25 °C (disoproxil fumarate salt) |
| LogP | 1.25 |
| Dissociation Constants | 3.75 |
COMPUTED DESCRIPTORS
| Molecular Weight | 519.4 g/mol |
|---|---|
| XLogP3 | 1.6 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 14 |
| Rotatable Bond Count | 17 |
| Exact Mass | 519.17302917 g/mol |
| Monoisotopic Mass | 519.17302917 g/mol |
| Topological Polar Surface Area | 185 Ų |
| Heavy Atom Count | 35 |
| Formal Charge | 0 |
| Complexity | 698 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Tenofovir disoproxil is an organic phosphonate that is the disoproxil ester of tenofovir. A prodrug for tenofovir, an HIV-1 reverse transcriptase inhibitor, tenofovir disoproxil is used as the fumaric acid salt in combination therapy for the treatment of HIV infection. It has a role as a prodrug, a HIV-1 reverse transcriptase inhibitor and an antiviral drug. It is functionally related to a tenofovir (anhydrous).