18378-89-7
Product Name:
MITHRAMYCIN A
Formula:
C52H76O24
Synonyms:
Aureolic acid;Mithramycin A - CAS 18378-89-7 - Calbiochem;Plicamycin;Plicamycin, Mithramycin
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CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Color/Form | YELLOW, CRYSTALLINE POWDER SHOWING BIREFRINGENCE |
| Odor | ODORLESS |
| Melting Point | 181.5 °C |
| Solubility | Sol in lower alcohols, acetone, ethyl acetate, water. Moderately sol in chloroform. Slightly sol in ether, benzene. |
| LogP | Log Kow = -0.25 at pH 7.4 |
| Stability/Shelf Life | HYGROSCOPIC, DECOMP SLOWLY IN LIGHT, & DECOMP IN HEAT |
| Optical Rotation | Specific optical rotation at 20 °C for D (sodium) line = -51 deg (c = 0.4 in ethanol) |
SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
COMPUTED DESCRIPTORS
| Molecular Weight | 1085.1 g/mol |
|---|---|
| XLogP3 | 0.6 |
| Hydrogen Bond Donor Count | 11 |
| Hydrogen Bond Acceptor Count | 24 |
| Rotatable Bond Count | 15 |
| Exact Mass | 1084.47265329 g/mol |
| Monoisotopic Mass | 1084.47265329 g/mol |
| Topological Polar Surface Area | 358 Ų |
| Heavy Atom Count | 76 |
| Formal Charge | 0 |
| Complexity | 1940 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 25 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Mithramycin is a carbohydrate-containing antibiotic, an anthracycline antibiotic, an aureolic acid and a secondary alpha-hydroxy ketone. It has a role as an antineoplastic agent, an EC 2.7.7.6 (RNA polymerase) inhibitor and a metabolite.