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1786-81-8

1786-81-8 structural image
Product Name: Propitocaine hydrochloride
Formula: C13H21ClN2O
Synonyms: N-(2-Methylphenyl)-2-(propylamino)propanamide hydrochloride;Prilocaine hydrochloride
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CHEMICAL AND PHYSICAL PROPERTIES

Collision Cross Section 154.2 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

COMPUTED DESCRIPTORS

Molecular Weight 256.77 g/mol
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 2
Rotatable Bond Count 5
Exact Mass 256.1342410 g/mol
Monoisotopic Mass 256.1342410 g/mol
Topological Polar Surface Area 41.1 Ų
Heavy Atom Count 17
Formal Charge 0
Complexity 218
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 2
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Prilocaine Hydrochloride is the hydrochloride salt form of prilocaine, an intermediate-acting local anesthetic of the amide type chemically related to lidocaine. Prilocaine hydrochloride binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of sodium ions. This leads to a stabilization of the neuronal membrane and inhibits depolarization and results in a reversible blockage of nerve impulse generation and propagation along nerve fibres and subsequent reversible loss of sensation.

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