CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Phorbol is a white solid. (NTP, 1992) |
|---|---|
| Color/Form | Anhydrous crystals; two forms of solvated crystals from ethyl acetate; solvated crystals from methanol or ethanol |
| Melting Point | 482 to 484 °F (solvent-free) (decomposes) (NTP, 1992) |
| Solubility | Quite soluble (NTP, 1992) |
| Density | Density of solvated phorbol: 1.2 g/cu cm, where solvated phorbol contains one phorbol molecule and one ethanol molecule. |
| Stability/Shelf Life | Phorbol is unstable to prolonged exposure to air, light and ambient temperatures. |
| Optical Rotation | Specific optical rotation (water): +102 deg at 24 °C/D; +118 deg at 20 °C/D (c = 0.4 in dioxane) |
| Decomposition | Decomposes at 250-251 °C (solvent free) |
| Other Experimental Properties | Phorbol is unstable to prolonged exposure to air, light and ambient temperatures. It is also sensitive to acid and alkalis and is subject to autooxidation. It dissolves slowly, therefore solution in a desired solvent is best accomplished by prolonged shaking under an inert atmosphere. |
| Chemical Classes | Biological Agents -> Plant Toxins |
SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
COMPUTED DESCRIPTORS
| Molecular Weight | 364.4 g/mol |
|---|---|
| XLogP3 | -0.8 |
| Hydrogen Bond Donor Count | 5 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 1 |
| Exact Mass | 364.18858861 g/mol |
| Monoisotopic Mass | 364.18858861 g/mol |
| Topological Polar Surface Area | 118 Ų |
| Heavy Atom Count | 26 |
| Formal Charge | 0 |
| Complexity | 753 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 8 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Phorbol is a white solid. (NTP, 1992)