165800-03-3
Product Name:
Linezolid
Formula:
C16H20FN3O4
Synonyms:
Linezolid;N-[[(5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide;PNU-100766;U-100766
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
Physical Description | Solid |
---|---|
Color/Form | White crystals from ethyl acetate and hexanes |
Melting Point | 154.5 |
Solubility | 3 mg/mL |
LogP | 0.9 |
Optical Rotation | Specific optical rotation at 20 °C for D (sodium) line = -9 deg (c = 0.919 in chloroform) |
Dissociation Constants | 1.8 |
SAFETY INFORMATION
Signal word | Danger |
---|---|
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H372:Specific target organ toxicity, repeated exposure |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. |
COMPUTED DESCRIPTORS
Molecular Weight | 337.35 g/mol |
---|---|
XLogP3 | 0.7 |
Hydrogen Bond Donor Count | 1 |
Hydrogen Bond Acceptor Count | 6 |
Rotatable Bond Count | 4 |
Exact Mass | 337.14378429 g/mol |
Monoisotopic Mass | 337.14378429 g/mol |
Topological Polar Surface Area | 71.1 Ų |
Heavy Atom Count | 24 |
Formal Charge | 0 |
Complexity | 472 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 1 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Linezolid is an organofluorine compound that consists of 1,3-oxazolidin-2-one bearing an N-3-fluoro-4-(morpholin-4-yl)phenyl group as well as an acetamidomethyl group at position 5. A synthetic antibacterial agent that inhibits bacterial protein synthesis by binding to a site on 23S ribosomal RNA of the 50S subunit and prevents further formation of a functional 70S initiation complex. It has a role as an antibacterial drug and a protein synthesis inhibitor. It is an oxazolidinone, a member of morpholines, an organofluorine compound and a member of acetamides.