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165800-03-3

165800-03-3 structural image
Product Name: Linezolid
Formula: C16H20FN3O4
Synonyms: Linezolid;N-[[(5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide;PNU-100766;U-100766
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CHEMICAL AND PHYSICAL PROPERTIES

Physical Description Solid
Color/Form White crystals from ethyl acetate and hexanes
Melting Point 154.5
Solubility 3 mg/mL
LogP 0.9
Optical Rotation Specific optical rotation at 20 °C for D (sodium) line = -9 deg (c = 0.919 in chloroform)
Dissociation Constants 1.8

SAFETY INFORMATION

Signal word Danger
Pictogram(s)

Health Hazard
GHS08
GHS Hazard Statements H372:Specific target organ toxicity, repeated exposure
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.

COMPUTED DESCRIPTORS

Molecular Weight 337.35 g/mol
XLogP3 0.7
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 4
Exact Mass 337.14378429 g/mol
Monoisotopic Mass 337.14378429 g/mol
Topological Polar Surface Area 71.1 Ų
Heavy Atom Count 24
Formal Charge 0
Complexity 472
Isotope Atom Count 0
Defined Atom Stereocenter Count 1
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Linezolid is an organofluorine compound that consists of 1,3-oxazolidin-2-one bearing an N-3-fluoro-4-(morpholin-4-yl)phenyl group as well as an acetamidomethyl group at position 5. A synthetic antibacterial agent that inhibits bacterial protein synthesis by binding to a site on 23S ribosomal RNA of the 50S subunit and prevents further formation of a functional 70S initiation complex. It is used for treating serious resistant Gram-positive bacterial infections, such as methicillin-resistant Staphylococcus aureus, penicillin-resistant Streptococcus, and vancomycin-resistant Enteroccocus, which blocks protein synthesis by binding to the 50S portion of the ribosome. Linezolid can be administered either intravenously or orally owing to its absolute bioavailability of close to 100%.

Pharmacokinetics

Linezolid is well absorbed, with a bioavailability of approximately 100% in healthy volunteers. This characteristic is a significant benefit, allowing this agent to be used early intravenously, then switched to oral, or even to commence infection treatment with oral therapy. After oral doses of 600 mg, steady-state peak serum concentrations (Cmax) are 15–27 mg/L and are reached 0.5–2 h after administration. The level of plasma protein binding is 31%, and the volume of distribution approximates the total body water content of 40–50 L. Plasma elimination half-life is 3.4–7.4 h. Linezolid is metabolized into two inactive metabolites, an aminoethoxyacetic acid (metabolite A) and a hydroxyethyl glycine (metabolite B). The clearance rate (±SD) is 80 ± 29 mL/min and by non-renal (65%) and renal mechanisms. Renal tubular reabsorption may occur. A proportion of the dose is excreted unchanged in the urine.

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