CHEMICAL AND PHYSICAL PROPERTIES
Boiling Point | 479.5 |
---|---|
Melting Point | 102-107 |
Solubility | Soluble |
LogP | 5.5 |
Dissociation Constants | 8.0 |
COMPUTED DESCRIPTORS
Molecular Weight | 307.5 g/mol |
---|---|
XLogP3 | 4.2 |
Hydrogen Bond Donor Count | 3 |
Hydrogen Bond Acceptor Count | 3 |
Rotatable Bond Count | 12 |
Exact Mass | 307.251129295 g/mol |
Monoisotopic Mass | 307.251129295 g/mol |
Topological Polar Surface Area | 66.5 Ų |
Heavy Atom Count | 22 |
Formal Charge | 0 |
Complexity | 258 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Fingolimod is an aminodiol that consists of propane-1,3-diol having amino and 2-(4-octylphenyl)ethyl substituents at the 2-position. It is a sphingosine 1-phosphate receptor modulator used for the treatment of relapsing-remitting multiple sclerosis. A prodrug, fingolimod is phosphorylated by sphingosine kinase to active metabolite fingolimod-phosphate, a structural analogue of sphingosine 1-phosphate. It has a role as an immunosuppressive agent, a prodrug, an antineoplastic agent, a sphingosine-1-phosphate receptor agonist and a CB1 receptor antagonist. It is an aminodiol and a primary amino compound. It is a conjugate base of a fingolimod(1+).