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157283-68-6

157283-68-6 structural image
Product Name: Travoprost
Formula: C26H35F3O6
Synonyms: (±)-16-(m-Trifluoromethylphenoxy)tetranorprostaglandin F2;Travoprost;Travoprost solution
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CHEMICAL AND PHYSICAL PROPERTIES

Physical Description Liquid
Solubility >16 mg/ml at 25.0°C
LogP 4.6

SAFETY INFORMATION

Signal word Danger
Pictogram(s)

Flame
Flammables
GHS02

Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H225:Flammable liquids
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233:Keep container tightly closed.
P240:Ground/bond container and receiving equipment.
P241:Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242:Use only non-sparking tools.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

COMPUTED DESCRIPTORS

Molecular Weight 500.5 g/mol
XLogP3 4.1
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 9
Rotatable Bond Count 13
Exact Mass 500.23857332 g/mol
Monoisotopic Mass 500.23857332 g/mol
Topological Polar Surface Area 96.2 Ų
Heavy Atom Count 35
Formal Charge 0
Complexity 693
Isotope Atom Count 0
Defined Atom Stereocenter Count 5
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 2
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Travoprost is the isopropyl ester of prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of travoprost are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. It is a pro-drug; the isopropyl ester group is hydrolysed by esterases in the cornea to the biologically active free acid, fluprostenol. It has a role as an antiglaucoma drug, an antihypertensive agent, a prodrug, an ophthalmology drug and a prostaglandin receptor agonist. It is a prostaglandins Falpha, a member of (trifluoromethyl)benzenes and an isopropyl ester. It is functionally related to a fluprostenol.

RELATED SUPPLIERS

Vepan Pharmatech Pvt Ltd

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Honour Lab Limited

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ANVI Pharma

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Chempifine Chemicals

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Sai Life Sciences Ltd

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Laurus Labs Ltd

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BDR Pharmaceuticals International Pvt Ltd

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Century Pharmaceuticals Ltd

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Aspen Biopharma Labs Pvt Ltd

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product:157283-68-6 98%
All suppliers(13)