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155213-67-5

155213-67-5 structural image
Product Name: Ritonavir
Formula: C37H48N6O5S2
Synonyms: ;Ritonavir
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CHEMICAL AND PHYSICAL PROPERTIES

Physical Description Solid
Color/Form White to light tan powder
Solubility Practically insoluble
Vapor Pressure 1.1X10-27 mm Hg @ 25 °C /Estimated/
LogP 3.9
Henry's Law Constant Henry's Law constant = 2.7X10-33 atm-cu m/mol @ 25 °C /Estimated/
Other Experimental Properties Hydroxyl radical reaction rate constant = 9.7X10-11 cu cm/molec-sec @ 25 °C /Estimated/

SAFETY INFORMATION

Signal word Warning
Pictogram(s)

Exclamation Mark
Irritant
GHS07
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

COMPUTED DESCRIPTORS

Molecular Weight 720.9 g/mol
XLogP3 6
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 9
Rotatable Bond Count 18
Exact Mass 720.31276100 g/mol
Monoisotopic Mass 720.31276100 g/mol
Topological Polar Surface Area 202 Ų
Heavy Atom Count 50
Formal Charge 0
Complexity 1040
Isotope Atom Count 0
Defined Atom Stereocenter Count 4
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

Description

Ritonavir is an L-valine derivative in which the alpha-amino group is acylated by a [(2-isopropyl-1,3-thiazol-4-yl)methyl]methylcarbamoyl group and a hydrogen of the carboxamide amino group is replaced by a (2R,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl group. As a CYP3A inhibitor and antiretroviral drug from the protease inhibitor class, it is used to treat HIV infection and AIDS, often in fixed-dose combination with another protease inhibitor, lopinavir. Additionally, ritonavir is used in combination with dasabuvir sodium hydrate, ombitasvir, and paritaprevir (under the trade name Viekira Pak) for the treatment of chronic hepatitis C virus genotype 1 infection and cirrhosis of the liver. Ritonavir serves as an antiviral drug, HIV protease inhibitor, environmental contaminant, and xenobiotic. It belongs to the classes of 1,3-thiazoles, L-valine derivatives, carbamate esters, ureas, and carboxamides.

RELATED SUPPLIERS

AVD pharmaceuticals Pvt Ltd

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Apotex Pharmachem India Pvt Ltd

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Aurobindo Pharma Limited

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Cipla Ltd

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Hetero Drugs Limited

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Venture Pharmaceuticals pvt ltd

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HRV Global Life Sciences

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Amara Labs Pvt Ltd

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Molsyns Research

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All suppliers(22)