150683-30-0
Product Name:
Tolvaptan
Formula:
C26H25ClN2O3
Synonyms:
N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide;OPC 41061
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Color/Form | Colorless prisms |
|---|---|
| Melting Point | 225.9 °C |
| Stability/Shelf Life | Stable under recommended storage conditions. |
COMPUTED DESCRIPTORS
| Molecular Weight | 448.9 g/mol |
|---|---|
| XLogP3 | 4.8 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 3 |
| Exact Mass | 448.1553704 g/mol |
| Monoisotopic Mass | 448.1553704 g/mol |
| Topological Polar Surface Area | 69.6 Ų |
| Heavy Atom Count | 32 |
| Formal Charge | 0 |
| Complexity | 674 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Tolvaptan is a benzazepine derivative incorporating a benzenedicarboxamide function whch is a selective vasopressin V2 receptor antagonist used to treat euvolemic and hypervolemic hyponatremia. It is also used in the treatment of rapidly progressing autosomal dominant polycystic kidney disease to slow the rate of cyst development and renal insufficiency. Tolvaptan is a racemate consisting of a 1:1 mixture of 5R and 5S stereomers. It has a role as a vasopressin receptor antagonist and an aquaretic. It is a benzazepine and a benzenedicarboxamide.