14976-57-9
Product Name:
Clemastine fumarate
Formula:
C25H30ClNO5
Synonyms:
Clemastine fumarate salt
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Color/Form | Colorless to faintly yellow crystalline powder |
|---|---|
| Odor | Odorless |
| Boiling Point | 154 °C at 0.02 mm Hg |
| Melting Point | 177-178 °C |
| Solubility | Very slightly soluble in water and sparingly soluble in alcohol. |
| Other Experimental Properties | 154 °C at 0.02 mm Hg (free base) |
SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
COMPUTED DESCRIPTORS
| Molecular Weight | 460.0 g/mol |
|---|---|
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 8 |
| Exact Mass | 459.1812508 g/mol |
| Monoisotopic Mass | 459.1812508 g/mol |
| Topological Polar Surface Area | 87.1 Ų |
| Heavy Atom Count | 32 |
| Formal Charge | 0 |
| Complexity | 495 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 1 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 2 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Clemastine fumarate is the fumaric acid salt of clemastine. An antihistamine with antimuscarinic and moderate sedative properties, it is used for the symptomatic relief of allergic conditions such as rhinitis, urticaria, conjunctivitis and in pruritic (severe itching) skin conditions. It has a role as a H1-receptor antagonist, an anti-allergic agent, a muscarinic antagonist and an antipruritic drug. It contains a clemastine.