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146464-95-1

146464-95-1 structural image
Product Name: 10-Propargyl-10-deazaaminopterin
Formula: C23H23N7O5
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CHEMICAL AND PHYSICAL PROPERTIES

Color/Form Off-white to yellow solid
Solubility Practically insoluble in shloroform and ethanol
Dissociation Constants 3.25, 4.76, and 6.17

SAFETY INFORMATION

Signal word Warning
Pictogram(s)

Exclamation Mark
Irritant
GHS07

Health Hazard
GHS08
GHS Hazard Statements H302:Acute toxicity,oral
H361:Reproductive toxicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P202:Do not handle until all safety precautions have been read and understood.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313:IF exposed or concerned: Get medical advice/attention.
P405:Store locked up.
P501:Dispose of contents/container to..…

COMPUTED DESCRIPTORS

Molecular Weight 477.5 g/mol
XLogP3 -0.9
Hydrogen Bond Donor Count 5
Hydrogen Bond Acceptor Count 11
Rotatable Bond Count 10
Exact Mass 477.17606686 g/mol
Monoisotopic Mass 477.17606686 g/mol
Topological Polar Surface Area 207 Ų
Heavy Atom Count 35
Formal Charge 0
Complexity 809
Isotope Atom Count 0
Defined Atom Stereocenter Count 1
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Pralatrexate is a pteridine that is the N-4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl derivative of L-glutamic acid. Used for treatment of Peripheral T-Cell Lymphoma, an aggressive form of non-Hodgkins lymphoma. It has a role as an antineoplastic agent, an antimetabolite and an EC 1.5.1.3 (dihydrofolate reductase) inhibitor. It is a N-acyl-L-glutamic acid, a member of pteridines and a terminal acetylenic compound.

RELATED SUPPLIERS

Laurus Labs Ltd

1Y
product:146464-95-1 Pralatrexate 98%

Apicore Pharmaceuticals Pvt Ltd

1Y
product:146464-95-1 98%
All suppliers(2)