144-82-1
Product Name:
SULFAMETHIZOLE
Formula:
C9H10N4O2S2
Synonyms:
N1-(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanilamide;4-Amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide;Sulfamethizole;Sulfamethylthiadiazole
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Sulfamethizole is a white powder. (NTP, 1992) |
|---|---|
| Color/Form | Crystals from water |
| Melting Point | 406 °F (NTP, 1992) |
| Solubility | >40.5 [ug/mL] (The mean of the results at pH 7.4) |
| LogP | 0.54 |
| LogS | -2.41 |
| Decomposition | When heated to decomposition it emits very toxic fumes of nitroxides and sulfoxides. |
| Dissociation Constants | pKa1 = 2.1 /amine/; pKa2 = 5.3 /R1SO2NHR2 moiety/ |
| Collision Cross Section | 155.2 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards] |
| Other Experimental Properties | The electronic absorption spectra of the Cu(II), Ni(II) and Co(II) chelates of the Schiff bases synthesized from 5-bromo-salicylaldehyde and sulfamethoxypyridazine, sulfamethizole and sulfafurazole (sulfisoxazole) were studied in dimethyl sulfoxide solution. All the chelates showed an intense charge transfer absorption band at the blue end of the visible region. The stereochemical characteristics of the chelates were illustrated by means of the absorptions caused by the d-d transitions. The Ni(II) and Co(II) chelates are 6 coordinated in all cases. |
SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H317:Sensitisation, Skin |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
COMPUTED DESCRIPTORS
| Molecular Weight | 270.3 g/mol |
|---|---|
| XLogP3 | 0.5 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 3 |
| Exact Mass | 270.02451792 g/mol |
| Monoisotopic Mass | 270.02451792 g/mol |
| Topological Polar Surface Area | 135 Ų |
| Heavy Atom Count | 17 |
| Formal Charge | 0 |
| Complexity | 349 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Sulfamethizole is a white powder. (NTP, 1992)