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1393477-72-9

1393477-72-9 structural image
Product Name: KPT-330
Formula: C17H11F6N7O
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CHEMICAL AND PHYSICAL PROPERTIES

Solubility 20mg/mL

COMPUTED DESCRIPTORS

Molecular Weight 443.3 g/mol
XLogP3 3
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 12
Rotatable Bond Count 5
Exact Mass 443.09292697 g/mol
Monoisotopic Mass 443.09292697 g/mol
Topological Polar Surface Area 97.6 Ų
Heavy Atom Count 31
Formal Charge 0
Complexity 621
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 1
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Selinexor is a first-in-class selective inhibitor of nuclear transport (SINE) compound. Selinexor, in combination with [bortezomib] and [dexamethasone], is currently approved for the treatment of multiple myeloma, a type of cancer formed from antibody-producing plasma cells. This condition is typically treated with high dose [bortezomib] and [dexamethasone] chemotherapy followed by an autologous stem-cell transplant. Other chemotherapies for multiple myeloma include [lenalidomide] and [dexamethasone], [thalidomide], and may include [melphalan] if the patient is not eligible for transplant. Selinexor was also granted accelerated approval for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) that have gone through at least 2 lines of systemic therapy. The FDA approved Selinexor in June 2019. The use of selinexor in combination with [bortezomib] and [dexamethasone] was approved by Health Canada in June 2022 for the treatment of multiple myeloma in adult patients who have received at least one prior therapy.

RELATED SUPPLIERS

Venkatasai Life Sciences

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product:1393477-72-9 Selinexor 99%
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